Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation
نویسندگان
چکیده
منابع مشابه
Role of CG and Non-CG Methylation in Immobilization of Transposons in Arabidopsis
Methylation of cytosine residues in eukaryotic genomes is often associated with repeated sequences including transposons and their derivatives. Methylation has been implicated in control of two potential deleterious effects of these repeats: (1) uncontrolled transcription, which often disturbs proper expression of nearby host genes, and (2) changes in genome structure by transposition and ectop...
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DNA methylation has roles in different biological processes such as gene regulation and imprinting. In Arabidopsis, DNA is methylated in three cytosine contexts: CG, CHG and CHH (where H denotes A, T or C)1. In mammals, DNA is primarily methylated in CG contexts; however, studies have uncovered the presence of non-CG methylation in certain cell types such as embryonic stem cells and brain cells...
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Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...
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Cytosine DNA methylation protects eukaryotic genomes by silencing transposons and harmful DNAs, but also regulates gene expression during normal development. Loss of CG methylation in the Arabidopsis thaliana met1 and ddm1 mutants causes varied and stochastic developmental defects that are often inherited independently of the original met1 or ddm1 mutation. Loss of non-CG methylation in plants ...
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From a mosaic of rather deep V and I images of the CG 30/CG 31 region we report distances and absorptions of these and other interesting interstellar features, the distances and absorptions estimates are based on shifting a new (V−I) 0 – M V relation obtained from nearby, presumably unreddened Hipparcos stars with luminosity class V classification to fit confining trends in the (V−I) – V diagra...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2018
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.03.009